Pretreatment Systemic Inflammatory Markers, Neutrophil Lymphocyte Ratio, and Platelet Lymphocyte Ratio as a Prognostic Factor in Cervical Cancer: A Retrospective Study

Inflammation has been recognized as a promoter of the neoplastic process initiation and progression. Neutrophilia, lymphocytopenia, thrombocytosis are hallmarks inflammatory reaction. The aim this study is to find correlation prognostic value pretreatment neutrophil lymphocyte ratio (NLR) platelet (PLR), with recurrence in carcinoma cervix. Data 208 biopsy-proven cases squamous cell cervix treated definitive chemoradiotherapy were retrospectively analyzed. Neutrophil, lymphocyte, count at diagnosis recorded NLR PLR calculated. cutoff calculated using receiver operator characteristics curve analysis. Correlation between locoregional (LRR) evaluated. Median age 50 years. International Federation Gynecology Obstetrics stage IIB was most prevalent study. statistically significantly affecting LRR. 2.45 sensitivity 82.6% specificity 77.7%. for 140.6 85.5% 80.6%. On univariate regression analysis (p = 0.045), tumor grade 0.001), addiction 0.024), < 0.001) associated Multivariate showed that 0.005) risk group independent factors Conclusion High correlate poor prognosis Hence, these biomarkers may be used surrogates prognosis.